Prazosin Overdose
Under the brand Minipress, prazosin was approved by the US Food and Drug Administration (FDA) to treat high blood pressure. Still, it is also known for treating posttraumatic stress disorder (PTSD) related nightmares and helping manage several other health conditions. This typically means it is combined with other prescription drugs, increasing the risk of drug interactions, adverse effects, and prazosin overdose.
What Is Prazosin?
Prazosin is a prescription medication that belongs to a class of drugs called alpha-blockers. Prazosin works by relaxing your blood vessels, allowing more blood flow through your body. It was the first alpha-adrenergic antagonist, or alpha-blocker, to be FDA-approved for use in the United States and is still widely used for the treatment of high blood pressure.
Side Effects of Prazosin
The most common prazosin side effect is feeling drowsy or dizzy, especially with the first dose. Although it is much less common, serious side effects can happen, and drinking alcohol can worsen them.
Common prazosin side effects include:
- Dizziness
- Drowsiness
- Lack of energy
- Weakness
- Nausea
- Headache
Adverse Effects of Prazosin
The adverse effects of prazosin include:
- Stomach aches
- Nausea and vomiting
- Diarrhea
- Stuffy nose
- Depression
- Dizziness and fainting
- Erectile dysfunction
- Painful, prolonged erection that can last hours
- Vertigo, a sensation that the environment around you is spinning or moving
- Kidney and liver damage
- Allergic reactions such as rash, hives, itching, blisters, fever, wheezing, trouble swallowing, and swelling of the face or tongue
Call your doctor and seek emergency medical treatment immediately if you experience any of these adverse effects.
Tell your doctor and pharmacists if you are allergic to alfuzosin (Uroxatral), doxazosin (Cardura), terazosin, or any ingredient in prazosin pills. They can provide you with a list of the ingredients.
People taking the prazosin drug may also develop intraoperative floppy iris syndrome (IFIS), known as small pupil syndrome, usually diagnosed during cataract surgery. This may hinder the removal of a cataract and lead to other eye complications.
Is Prazosin Addictive?
Prazosin isn’t addictive like most drugs, but it does have a potential for abuse. Prazosin can result in psychological dependence causing people to use it recreationally and mix it with other drugs.
Prevent Prazosin Overdose
Although prazosin isn’t as dangerous as opioids or benzodiazepines, it isn’t entirely safe. A prazosin overdose can happen if you take too much of the medication. It can also occur because of adverse drug reactions from combining other prescription medications, nonprescription medicines, illicit drugs, vitamins, nutritional supplements, or herbal products.
Prazosin can have negative drug interactions with the following medications:
- Beta-blockers such as propranolol (Inderal, InnoPran, Inderide)
- Medications for erectile dysfunction such as vardenafil (Levitra, Stazyn), sildenafil (Revatio, Viagra), or tadalafil (Adcirca, Cialis)
- Other medicines for high blood pressure
You can prevent a prazosin overdose by following your doctor’s directions and telling them and your pharmacist what other drugs you are taking or plan to take. It’s essential to stay informed about your medications and any products you may be taking, like dietary supplements and minerals.
Symptoms of a Prazosin Overdose
The symptoms of a prazosin overdose include:
- Loss of consciousness
- Rapid or irregular heart
- Trouble breathing
- Blurred vision
If you suspect an overdose, call 911 immediately. Although there isn’t an antidote for prazosin overdose, treatment may include pumping the person’s stomach, stabilizing their blood pressure, and using medications to counteract the effects of the overdose.
Treatment for Prazosin Abuse
If you or a loved one is struggling with drug and alcohol abuse, compassionate evidence-based drug addiction treatment is available.
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- Anderson, C. et al., “Refractory Hypotension Caused by Prazzosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of Literature.” The Journal of Emergency Medicine, Oct. 2018.
- “Prazosin.” LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Jan. 2018.
- “Prazosin.” MedlinePlus: National Library of Medicine, Aug. 2018.
- Basquez, R. & Pippin, M.M., “Prazsoin.” StatPearls Publishing, Jan. 2023.
Medical Disclaimer: